Source:
Tomlins, S. A., Mehra, R., Rhodes, D. R., Cao, X., Wang, L., Dhanasekaran, S. M., ... & Shah, R. B. (2007). Integrative molecular concept modeling of prostate cancer progression. Nature genetics, 39(1), 41.
Original data:
http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE6099
Description:
Despite efforts to
profile prostate cancer (PCA), the genetic alterations and biological processes
that correlate with the observed histological progression are unclear. Using
laser-capture microdissection to isolate
101 cell populations, the authors have profiled prostate cancer
progression from benign epithelium (EPI),
including putative precursor lesions prostatic intraepithelial neoplasia
(PIN), to metastatic disease (MET). Also,
by profiling stromal (STROMA) and epithelial cell populations, they defined a
stromal signature, which was used aid their analyses.
Sample distribution: