Source:
Bittner, M., Meltzer, P., Chen, Y., & Jiang, Y. (2000). Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature, 406(6795), 536.
Original data:
http://research.nhgri.nih.gov/microarray/Melanoma_Supplement/Files/gene_list-Cutaneous_Melanoma.xls
Description:
The authors report the
discovery of a subset of melanomas identified by mathematical analysis of gene
expression in a series of samples. In order to so, they gathered expression
profile for 38 samples, including 31 melanomas and 7 controls. The resulting
hierarchical clustering of the 31 melanoma samples demonstrates that 19 samples
are tightly clustered. We denote the class of these samples by ML1. The others,
including the 7 controls, will be referred to as ML2.
Sample distribution: